Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1

Oxidative stress and atherosclerosis-related vascular disorders are risk factors for cognitive decline with aging. In a small clinical study in men, testosterone improved cognitive function; however, it is unknown how testosterone ameliorates the pathogenesis of cognitive decline with aging. Here, w...

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Bibliographische Detailangaben
Hauptverfasser: Ota, Hidetaka, Akishita, Masahiro, Akiyoshi, Takuyu, Kahyo, Tomoaki, Setou, Mitsutoshi, Ogawa, Sumito, Iijima, Katsuya, Eto, Masato, Ouchi, Yasuyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251570/
https://ncbi.nlm.nih.gov/pubmed/22238626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029598
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