Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with insulin resistance phenotypes (higher fasting insulin adjusted for BMI, lower...

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Vydáno v:Nat Genet
Hlavní autoři: Lotta, Luca A., Gulati, Pawan, Day, Felix R., Payne, Felicity, Ongen, Halit, van de Bunt, Martijn, Gaulton, Kyle J., Eicher, John D., Sharp, Stephen J., Luan, Jian’an, De Lucia Rolfe, Emanuella, Stewart, Isobel D., Wheeler, Eleanor, Willems, Sara M., Adams, Claire, Yaghootkar, Hanieh, Forouhi, Nita G., Khaw, Kay-Tee, Johnson, Andrew D., Semple, Robert K., Frayling, Timothy, Perry, John R. B., Dermitzakis, Emmanouil, McCarthy, Mark I., Barroso, Inês, Wareham, Nicholas J., Savage, David B., Langenberg, Claudia, O’Rahilly, Stephen, Scott, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774584/
https://ncbi.nlm.nih.gov/pubmed/27841877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3714
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