AG490 ameliorates early brain injury via inhibition of JAK2/STAT3-mediated regulation of HMGB1 in subarachnoid hemorrhage

High mobility group box 1 (HMGB1) is a classic damage-associated molecular pattern that has an important role in the pathological inflammatory response. In vitro studies have demonstrated that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is i...

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Publicado en:Exp Ther Med
Autores principales: An, Ji-Yang, Pang, Hong-Gang, Huang, Ting-Qin, Song, Jin-Ning, Li, Dan-Dong, Zhao, Yong-Lin, Ma, Xu-Dong
Formato: Artigo
Lenguaje:Inglês
Publicado: D.A. Spandidos 2018
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774435/
https://ncbi.nlm.nih.gov/pubmed/29434719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2017.5539
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