Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity

Naïve T cells are poorly studied in cancer patients. We report that naïve T cells are prone to undergo apoptosis due to a selective loss of FAK family–interacting protein of 200 kDa (FIP200) in ovarian cancer patients and tumor-bearing mice. This results in poor antitumor immunity via autophagy defi...

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Detaylı Bibliyografya
Yayımlandı:Sci Immunol
Asıl Yazarlar: Xia, Houjun, Wang, Wei, Crespo, Joel, Kryczek, Ilona, Li, Wei, Wei, Shuang, Bian, Zhaoqun, Maj, Tomasz, He, Mingxiao, Liu, Rebecca J., He, Youwen, Rattan, Ramandeep, Munkarah, Adnan, Guan, Jun-Lin, Zou, Weiping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774333/
https://ncbi.nlm.nih.gov/pubmed/29150439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aan4631
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