Evolutionarily conserved roles for blood-brain barrier xenobiotic transporters in endogenous steroid partitioning and behavior

CNS chemical protection depends upon discrete control of small-molecule access by the blood-brain barrier (BBB). Curiously, some drugs cause CNS side effects despite negligible transit past the BBB. To investigate this phenomenon, we asked whether the highly BBB-enriched drug efflux transporter Mdr1...

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Vydáno v:Cell Rep
Hlavní autoři: Hindle, Samantha J., Munji, Roeben N., Dolghih, Elena, Gaskins, Garrett, Orng, Souvinh, Ishimoto, Hiroshi, Soung, Allison, DeSalvo, Michael, Kitamoto, Toshihiro, Keiser, Michael J., Jacobson, Matthew P., Daneman, Richard, Bainton, Roland J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774027/
https://ncbi.nlm.nih.gov/pubmed/29091768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.026
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