Evolutionarily conserved roles for blood-brain barrier xenobiotic transporters in endogenous steroid partitioning and behavior

CNS chemical protection depends upon discrete control of small-molecule access by the blood-brain barrier (BBB). Curiously, some drugs cause CNS side effects despite negligible transit past the BBB. To investigate this phenomenon, we asked whether the highly BBB-enriched drug efflux transporter Mdr1...

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Pubblicato in:Cell Rep
Autori principali: Hindle, Samantha J., Munji, Roeben N., Dolghih, Elena, Gaskins, Garrett, Orng, Souvinh, Ishimoto, Hiroshi, Soung, Allison, DeSalvo, Michael, Kitamoto, Toshihiro, Keiser, Michael J., Jacobson, Matthew P., Daneman, Richard, Bainton, Roland J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774027/
https://ncbi.nlm.nih.gov/pubmed/29091768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.026
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