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Microtubule Polymerization and Cross-Link Dynamics Explain Axonal Stiffness and Damage

Axonal damage is a critical indicator for traumatic effects of physical impact to the brain. However, the precise mechanisms of axonal damage are still unclear. Here, we establish a mechanistic and highly dynamic model of the axon to explore the evolution of damage in response to physical forces. Ou...

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: de Rooij, Rijk, Kuhl, Ellen
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773766/
https://ncbi.nlm.nih.gov/pubmed/29320687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.11.010
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