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Sharing of Phosphatases Promotes Response Plasticity in Phosphorylation Cascades

Sharing of positive or negative regulators between multiple targets is frequently observed in cellular signaling cascades. For instance, phosphatase sharing between multiple kinases is ubiquitous within the MAPK pathway. Here we investigate how such phosphatase sharing could shape robustness and evo...

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Vydáno v:Biophys J
Hlavní autoři: Ghosh, Bhaswar, Sarma, Uddipan, Sourjik, Victor, Legewie, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773761/
https://ncbi.nlm.nih.gov/pubmed/29320690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.037
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