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Treprostinil inhibits proliferation and extracellular matrix deposition by fibroblasts through cAMP activation
Idiopathic pulmonary fibrosis (IPF) is characterized by peripheral lung fibrosis and increased interstitial extracellular matrix (ECM) deposition. In IPF, tumor growth factor (TGF)-β1 which is the major stimulus of ECM deposition, and platelet derived growth factor (PDGF)-BB is a potent stimulus of...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5773699/ https://ncbi.nlm.nih.gov/pubmed/29348469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19294-1 |
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