Increased diversity with reduced “diversity evenness” of tumor infiltrating T-cells for the successful cancer immunotherapy

To facilitate the optimization of cancer immunotherapy lacking immune-related adverse events, we performed TCR repertoire analysis of tumor-infiltrating CD8(+) T-cells in B16 melanoma-bearing mice receiving anti-PD-1, anti-CTLA-4, anti-4-1BB, anti-CD4 or a combination of anti-PD-1 and 4-1BB antibodi...

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Publicado en:Sci Rep
Autores principales: Hosoi, Akihiro, Takeda, Kazuyoshi, Nagaoka, Koji, Iino, Tamaki, Matsushita, Hirokazu, Ueha, Satoshi, Aoki, Shin, Matsushima, Kouji, Kubo, Masato, Morikawa, Teppei, Kitaura, Kazutaka, Suzuki, Ryuji, Kakimi, Kazuhiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773695/
https://ncbi.nlm.nih.gov/pubmed/29348598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19548-y
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