The nitric oxide radical scavenger carboxy-PTIO reduces the immunosuppressive activity of myeloid-derived suppressor cells and potentiates the antitumor activity of adoptive cytotoxic T lymphocyte immunotherapy

Adoptive immunotherapy with cytotoxic T lymphocytes (CTLs) can result in robust and durable antitumor responses. Tumor-infiltrating CTLs produce IFNγ and mediate antitumor activity, but they simultaneously induce counter-regulatory immunosuppressive mechanisms in the tumor by recruiting monocytic my...

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Vydáno v:Oncoimmunology
Hlavní autoři: Hirano, Kosuke, Hosoi, Akihiro, Matsushita, Hirokazu, Iino, Tamaki, Ueha, Satoshi, Matsushima, Kouji, Seto, Yasuyuki, Kakimi, Kazuhiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570109/
https://ncbi.nlm.nih.gov/pubmed/26405569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1019195
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