Prime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge

Vaccine development against Plasmodium vivax malaria lags behind that for Plasmodium falciparum. To narrow this gap, we administered recombinant antigens based on P. vivax circumsporozoite protein (CSP) to mice. We expressed in Pichia pastoris two chimeric proteins by merging the three central repea...

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Publicat a:Sci Rep
Autors principals: de Camargo, Tarsila Mendes, de Freitas, Elisângela Oliveira, Gimenez, Alba Marina, Lima, Luciana Chagas, de Almeida Caramico, Karina, Françoso, Kátia Sanches, Bruna-Romero, Oscar, Andolina, Chiara, Nosten, François, Rénia, Laurent, Ertl, Hildegund C. J., Nussenzweig, Ruth S., Nussenzweig, Victor, Rodrigues, Mauricio M., Reyes-Sandoval, Arturo, Soares, Irene S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773670/
https://ncbi.nlm.nih.gov/pubmed/29348479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-19063-6
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