Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

Defects in endolysosomal and autophagic functions are increasingly viewed as key pathological features of neurodegenerative disorders. A master regulator of these functions is phosphatidylinositol-3-phosphate (PI3P), a phospholipid synthesized primarily by class III PI 3-kinase Vps34. Here we report...

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Publicat a:Nat Commun
Autors principals: Miranda, André M., Lasiecka, Zofia M., Xu, Yimeng, Neufeld, Jessi, Shahriar, Sanjid, Simoes, Sabrina, Chan, Robin B., Oliveira, Tiago Gil, Small, Scott A., Di Paolo, Gilbert
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773483/
https://ncbi.nlm.nih.gov/pubmed/29348617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02533-w
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