Histone deacetylation, as opposed to promoter methylation, results in epigenetic BIM silencing and resistance to EGFR TKI in NSCLC

Drug resistance remains a major challenge in epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. Bcl-2-like protein 11 (BIM), a B-cell lymphoma 2 family pro-apoptotic protein, is a prime target for specific anti-cancer therapeutics. However, the epigenetic regulation of BI...

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Veröffentlicht in:Oncol Lett
Hauptverfasser: Zhao, Mingchuan, Zhang, Yishi, Li, Jiayu, Li, Xuefei, Cheng, Ningning, Wang, Qi, Cai, Weijing, Zhao, Chao, He, Yayi, Chang, Jianhua, Zhou, Caicun
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2018
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772734/
https://ncbi.nlm.nih.gov/pubmed/29399169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.7411
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