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House dust mite induced allergic airway disease is attenuated in CD11c(cre)IL-4Rα(−/l)°(x) mice

The precise mechanisms leading to development of T helper type (Th)2-driven allergic responses are unknown. We aimed to determine how IL-4 receptor alpha (IL-4Rα) signaling on CD11c(+) cells influences allergen-induced Th2 responses in mice. CD11c(cre)IL-4Rα(−/l)°(x) mice, deficient in IL-4Rα on den...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nieuwenhuizen, Natalie Eva, Kirstein, Frank, Hoving, Jennifer Claire, Brombacher, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772663/
https://ncbi.nlm.nih.gov/pubmed/29343807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-19060-9
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