MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-derived metabolites presented on MR1. Here we show, using a controlled infection of humans with live Salmonella enterica serovar Paratyphi A, that MAIT cells are activated during infection, an effect maintai...

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Udgivet i:Nat Commun
Main Authors: Howson, Lauren J., Napolitani, Giorgio, Shepherd, Dawn, Ghadbane, Hemza, Kurupati, Prathiba, Preciado-Llanes, Lorena, Rei, Margarida, Dobinson, Hazel C., Gibani, Malick M., Teng, Karen Wei Weng, Newell, Evan W., Veerapen, Natacha, Besra, Gurdyal S., Pollard, Andrew J., Cerundolo, Vincenzo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772558/
https://ncbi.nlm.nih.gov/pubmed/29343684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02540-x
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