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Sensing Native Protein Solution Structures Using a Solid-state Nanopore: Unraveling the States of VEGF

Monitoring individual proteins in solution while simultaneously obtaining tertiary and quaternary structural information is challenging. In this study, translocation of the vascular endothelial growth factor (VEGF) protein through a solid-state nanopore (ssNP) produces distinct ion-current blockade...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Varongchayakul, Nitinun, Huttner, Diana, Grinstaff, Mark W., Meller, Amit
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772516/
https://ncbi.nlm.nih.gov/pubmed/29343861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19332-y
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