Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2

Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and heterogeneity remains largely unknown, hampering their clinical use. Hi...

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Gepubliceerd in:Immunity
Hoofdauteurs: Sander, Jil, Schmidt, Susanne V., Cirovic, Branko, McGovern, Naomi, Papantonopoulou, Olympia, Hardt, Anna-Lena, Aschenbrenner, Anna C., Kreer, Christoph, Quast, Thomas, Xu, Alexander M., Schmidleithner, Lisa M., Theis, Heidi, Thi Huong, Lan Do, Sumatoh, Hermi Rizal Bin, Lauterbach, Mario A.R., Schulte-Schrepping, Jonas, Günther, Patrick, Xue, Jia, Baßler, Kevin, Ulas, Thomas, Klee, Kathrin, Katzmarski, Natalie, Herresthal, Stefanie, Krebs, Wolfgang, Martin, Bianca, Latz, Eicke, Händler, Kristian, Kraut, Michael, Kolanus, Waldemar, Beyer, Marc, Falk, Christine S., Wiegmann, Bettina, Burgdorf, Sven, Melosh, Nicholas A., Newell, Evan W., Ginhoux, Florent, Schlitzer, Andreas, Schultze, Joachim L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772172/
https://ncbi.nlm.nih.gov/pubmed/29262348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.11.024
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