Vitamin C sensitizes melanoma to BET inhibitors

Bromodomain and extra-terminal inhibitors (BETi) are promising cancer therapies, yet prominent side effects of BETi at effective doses have been reported in Phase I clinical trials. Here we screened a panel of small molecules targeting epigenetic modulators against human metastatic melanoma cells. C...

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Udgivet i:Cancer Res
Main Authors: Mustafi, Sushmita, Camarena, Vladimir, Volmar, Claude-Henry, Huff, Tyler C., Sant, David W., Brothers, Shaun P., Liu, Zhao-Jun, Wahlestedt, Claes, Wang, Gaofeng
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771981/
https://ncbi.nlm.nih.gov/pubmed/29180474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2040
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