Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer

BACKGROUND: Bromodomain and extra-terminal inhibitors (BETi) have shown efficacy for the treatment of aggressive triple negative breast cancer (TNBC). However, BETi are plagued by a narrow therapeutic window as manifested by severe toxicities at effective doses. Therefore, it is a limitation to thei...

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Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: Mustafi, Sushmita, Camarena, Vladimir, Qureshi, Rehana, Yoon, Hyunho, Volmar, Claude-Henry, Huff, Tyler C., Sant, David W., Zheng, Lihong, Brothers, Shaun P., Wahlestedt, Claes, Slingerland, Joyce, Wang, Gaofeng
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557781/
https://ncbi.nlm.nih.gov/pubmed/30975544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.04.006
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