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Site-specific glycan heterogeneity characterization by HILIC solid-phase extraction, RPLC fractionation, and capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry

Reversed-phase chromatographic separation of glycopeptides tends to be dominated by the peptide composition. In contrast, capillary zone electrophoresis separation of glycopeptides is particularly sensitive to the sialic acid composition of the glycan. In this paper, we combine the two techniques to...

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Publicat a:Anal Chem
Autors principals: Qu, Yanyan, Sun, Liangliang, Zhang, Zhenbin, Dovichi, Norman J.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771954/
https://ncbi.nlm.nih.gov/pubmed/29231704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b03912
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