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Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje cell-Dependent Ventricular Arrhythmias

BACKGROUND: In human cardiac ventricle, I(K1) is mainly comprised of Kir2.1, but Kir2.2 and Kir2.3 heterotetramers occur and modulate I(K1.) LQT9-associated CAV3 mutations cause decreased Kir2.1 current density, but Kir2.x heterotetramers have not been studied. Here we determine the effect of LQT9-C...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Vaidyanathan, Ravi, Van Ert, Hanora, Haq, Kazi T, Morotti, Stefano, Esch, Samuel, McCune, Elise C., Grandi, Eleonora, Eckhardt, Lee L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771420/
https://ncbi.nlm.nih.gov/pubmed/29326130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005800
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