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Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene‐induced lung tumors in aged mice

Aging is often accompanied by a dramatic increase in cancer susceptibility. To gain insights into how aging affects tumor susceptibility, we generated a conditional mouse model in which oncogenic Kras (G12D) was activated specifically in lungs of young (3–5 months) and old (19–24 months) mice. Activ...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Aging Cell
Κύριοι συγγραφείς: Parikh, Neha, Shuck, Ryan L., Gagea, Mihai, Shen, Lanlan, Donehower, Lawrence A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: John Wiley and Sons Inc. 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771401/
https://ncbi.nlm.nih.gov/pubmed/29047229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12691
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