Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy

Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Liu, Pei-Feng, Tsai, Kun-Lin, Hsu, Chien-Jen, Tsai, Wei-Lun, Cheng, Jin-Shiung, Chang, Hsueh-Wei, Shiau, Chung-Wai, Goan, Yih-Gang, Tseng, Ho-Hsing, Wu, Chih-Hsuan, Reed, John C., Yang, Lee-Wei, Shu, Chih-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771097/
https://ncbi.nlm.nih.gov/pubmed/29344310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22012
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