Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy

Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Theranostics
Egile Nagusiak: Liu, Pei-Feng, Tsai, Kun-Lin, Hsu, Chien-Jen, Tsai, Wei-Lun, Cheng, Jin-Shiung, Chang, Hsueh-Wei, Shiau, Chung-Wai, Goan, Yih-Gang, Tseng, Ho-Hsing, Wu, Chih-Hsuan, Reed, John C., Yang, Lee-Wei, Shu, Chih-Wen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Ivyspring International Publisher 2018
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771097/
https://ncbi.nlm.nih.gov/pubmed/29344310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22012
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