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In Vivo Detection of CPP-115 Target Engagement in Human Brain
CPP-115, a next-generation γ-amino butyric acid (GABA)-aminotransferase (AT) inhibitor, shows comparable pharmacokinetics, improved safety and tolerability, and a more favorable toxicity profile when compared with vigabatrin. The pharmacodynamic characteristics of CPP-115 remain to be evaluated. The...
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| Pubblicato in: | Neuropsychopharmacology |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770752/ https://ncbi.nlm.nih.gov/pubmed/28741622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.156 |
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