Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking

Anoikis acts as a critical barrier to metastasis by inducing cell death upon cancer cell detachment from the extracellular matrix (ECM), thereby preventing tumor cell dissemination to secondary sites. The induction of anoikis requires the lysosomal-mediated downregulation of epidermal growth factor...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Corkery, D P, Clarke, L E, Gebremeskel, S, Salsman, J, Pinder, J, Le Page, C, Meunier, L, Xu, Z, Mes-Masson, A-M, Berman, J N, Johnston, B, Dellaire, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770602/
https://ncbi.nlm.nih.gov/pubmed/28892043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.318
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