Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila

Ubiquitin-mediated protein degradation plays essential roles in proteostasis and is involved in the pathogenesis of neurodegenerative diseases in which ubiquitin-positive aberrant proteins accumulate. However, how such aberrant proteins are processed inside cells has not been fully explored. Here, w...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Uechi, Hiroyuki, Kuranaga, Erina, Iriki, Tomohiro, Takano, Kohei, Hirayama, Shoshiro, Miura, Masayuki, Hamazaki, Jun, Murata, Shigeo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770533/
https://ncbi.nlm.nih.gov/pubmed/29109084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00195-17
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