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Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process
The intracellular accumulation of unfolded or misfolded proteins is believed to contribute to aging and age-related neurodegenerative diseases. However, the links between age-dependent proteotoxicity and cellular protein degradation systems remain poorly understood. Here, we show that 26S proteasome...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643801/ https://ncbi.nlm.nih.gov/pubmed/19075009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01227-08 |
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