Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

The transcription factor ISL1 is thought to be key for conveying the multipotent and proliferative properties of cardiac precursor cells. Here, we investigate its function upon cardiac induction of human embryonic stem cells. We find that ISL1 does not stabilize the transient cardiac precursor cell...

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Publicado en:eLife
Autores principales: Quaranta, Roberto, Fell, Jakob, Rühle, Frank, Rao, Jyoti, Piccini, Ilaria, Araúzo-Bravo, Marcos J, Verkerk, Arie O, Stoll, Monika, Greber, Boris
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770158/
https://ncbi.nlm.nih.gov/pubmed/29337667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31706
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