Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway

Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in inflammation and cancer targeted by nonsteroidal anti-inflammatory drugs. COX-2 is also expressed constitutively in discreet locations where its inhibition drives gastrointestinal and cardiovascular/renal side effects. Constitutive COX-2 e...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Kirkby, Nicholas S., Sampaio, Walkyria, Etelvino, Gisele, Alves, Daniele T., Anders, Katie L., Temponi, Rafael, Shala, Fisnik, Nair, Anitha S., Ahmetaj-Shala, Blerina, Jiao, Jing, Herschman, Harvey R., Wang, Xiaomeng, Wahli, Walter, Santos, Robson A., Mitchell, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott, Williams & Wilkins 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770101/
https://ncbi.nlm.nih.gov/pubmed/29295852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09906
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