IGF1R Protein Expression is Not Associated with Differential Benefit to Concurrent Trastuzumab in Early-Stage HER2-positive Breast Cancer from the North Central Cancer Treatment Group (Alliance) Adjuvant Trastuzumab Trial N9831

BACKGROUND: Preclinical evidence indicates that increased insulin-like growth factor receptor-1 (IGF1R) signaling interferes with the action of trastuzumab suggesting a possible mechanism of trastuzumab resistance. Thus, we evaluated IGF1R prevalence, relationship with demographic data, and associat...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Reinholz, Monica M., Chen, Beiyun, Dueck, Amylou C., Tenner, Kathleen, Ballman, Karla, Riehle, Darren, Jenkins, Robert B., Geiger, Xochiquetzal J., McCullough, Ann E, Perez, Edith A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769872/
https://ncbi.nlm.nih.gov/pubmed/28533226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0574
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