Association Studies of Fcγ Receptor Polymorphisms with Outcome in HER2+ Breast Cancer Patients Treated with Trastuzumab in NCCTG (Alliance) Trial N9831

Patients with HER2(+) breast cancer treated with trastuzumab and chemotherapy have superior survival compared to patients treated with chemotherapy alone. Polymorphisms within FCGR2A and FCGR3A are associated with binding affinity of natural killer cells to the IgG1 portion of trastuzumab and a poly...

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Главные авторы: Norton, Nadine, Olson, Rebecca M., Pegram, Mark, Tenner, Kathleen, Ballman, Karla V., Clynes, Raphael, Knutson, Keith L., Perez, Edith A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215796/
https://ncbi.nlm.nih.gov/pubmed/24989892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0059
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