NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy

NAD metabolism and the NAD biosynthetic enzymes nicotinamide nucleotide adenylyltransferases (NMNATs) are thought to play a key neuroprotective role in tauopathies, including Alzheimer’s disease. Here, we investigated whether modulating the expression of the NMNAT nuclear isoform NMNAT1, which is im...

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Detalhes bibliográficos
Publicado no:Behav Brain Res
Main Authors: Rossi, Francesca, Geiszler, Philippine C., Meng, Weina, Barron, Matthew R., Prior, Malcolm, Herd-Smith, Anna, Loreto, Andrea, Lopez, Maria Yanez, Faas, Henryk, Pardon, Marie-Christine, Conforti, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier/North-Holland Biomedical Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769520/
https://ncbi.nlm.nih.gov/pubmed/29175372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2017.11.030
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