Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma

In fibrolamellar hepatocellular carcinoma a single genetic deletion results in the fusion of the first exon of the heat shock protein 40, DNAJB1, which encodes the J domain, with exons 2–10 of the catalytic subunit of protein kinase A, PRKACA. This produces an enzymatically active chimeric protein J...

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Publicat a:Sci Rep
Autors principals: Tomasini, Michael D., Wang, Yingjie, Karamafrooz, Adak, Li, Geoffrey, Beuming, Thijs, Gao, Jiali, Taylor, Susan S., Veglia, Gianluigi, Simon, Sanford M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768683/
https://ncbi.nlm.nih.gov/pubmed/29335433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18956-w
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