Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors

Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types self-patterning into a polarized, laminated architecture. In static cultures, organoid development may be hindered by limitations in diffusion of oxygen and nutrients. Herein, we report a bioprocess using r...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: DiStefano, Tyler, Chen, Holly Yu, Panebianco, Christopher, Kaya, Koray Dogan, Brooks, Matthew J., Gieser, Linn, Morgan, Nicole Y., Pohida, Tom, Swaroop, Anand
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768666/
https://ncbi.nlm.nih.gov/pubmed/29233554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.11.001
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