Pediatric Anaplastic Embryonal Rhabdomyosarcoma: Targeted Therapy Guided by Genetic Analysis and a Patient-Derived Xenograft Study

Therapy for rhabdomyosarcoma (RMS) has generally been limited to combinations of conventional cytotoxic agents similar to regimens originally developed in the late 1960s. Recently, identification of molecular alterations through next-generation sequencing of individual tumor specimens has facilitate...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Cramer, Stuart L., Miller, Aubrey L., Pressey, Joseph G., Gamblin, Tracy L., Beierle, Elizabeth A., Kulbersh, Brian D., Garcia, Patrick L., Council, Leona N., Radhakrishnan, Rupa, Hendrix, Skyler V., Kelly, David R., Watts, Raymond G., Yoon, Karina J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768639/
https://ncbi.nlm.nih.gov/pubmed/29376028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00327
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