IL-1R8 is a checkpoint in NK cells regulating anti-tumor and anti-viral activity

Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalin...

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Udgivet i:Nature
Main Authors: Molgora, Martina, Bonavita, Eduardo, Ponzetta, Andrea, Riva, Federica, Barbagallo, Marialuisa, Jaillon, Sébastien, Popović, Branka, Bernardini, Giovanni, Magrini, Elena, Gianni, Francesca, Zelenay, Santiago, Jonjić, Stipan, Santoni, Angela, Garlanda, Cecilia, Mantovani, Alberto
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768243/
https://ncbi.nlm.nih.gov/pubmed/29072292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24293
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