MLN4924 neddylation inhibitor promotes cell death in paclitaxel-resistant human lung adenocarcinoma cells

Acquired resistance to first-line chemotherapeutics, including paclitaxel (PTX), is a primary factor contributing to chemotherapy failure in non-small cell lung cancer (NSCLC) patients. Previous studies have identified that targeting NEDD8-activating enzyme (NAE) with MLN4924 effectively overcomes p...

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Pubblicato in:Oncol Lett
Autori principali: Xu, Qiang, Lin, Guibin, Xu, Huizhe, Hu, Lulu, Wang, Yupeng, Du, Sha, Deng, Wuguo, Hu, Wenxian, Cheng, Wei, Jiang, Ke
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768125/
https://ncbi.nlm.nih.gov/pubmed/29387232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.7314
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