Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes

The generation of clinical good manufacturing practices (GMP)-grade adeno-associated virus (AAV) vectors requires purification strategies that support the generation of vectors of high purity, and that exhibit a good safety and efficacy profile. To date, most reported purification schemas are seroty...

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Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Nass, Shelley A., Mattingly, Maryellen A., Woodcock, Denise A., Burnham, Brenda L., Ardinger, Jeffrey A., Osmond, Shayla E., Frederick, Amy M., Scaria, Abraham, Cheng, Seng H., O’Riordan, Catherine R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767896/
https://ncbi.nlm.nih.gov/pubmed/29349097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.12.004
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