Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling

ATP-binding cassette (ABC) transporters help export various substrates across the cell membrane and significantly contribute to drug resistance. However, a recent study reported an unusual case in which the loss of an ABC transporter in Candida albicans, orf19.4531 (previously named ROA1), increases...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Khandelwal, Nitesh Kumar, Chauhan, Neeraj, Sarkar, Parijat, Esquivel, Brooke D., Coccetti, Paola, Singh, Ashutosh, Coste, Alix T., Gupta, Meghna, Sanglard, Dominique, White, Theodore C., Chauvel, Murielle, d'Enfert, Christophe, Chattopadhyay, Amitabha, Gaur, Naseem A., Mondal, Alok Kumar, Prasad, Rajendra
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Membrane Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767851/
https://ncbi.nlm.nih.gov/pubmed/29158264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.807032
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