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Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer
Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair (MMR). About 15% of sporadic colorectal cancers (CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono- and di-nucleotide frameshifts to classify it as microsatellite instabili...
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| Udgivet i: | World J Gastrointest Oncol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Baishideng Publishing Group Inc
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5767788/ https://ncbi.nlm.nih.gov/pubmed/29375743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4251/wjgo.v10.i1.1 |
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