Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

INTRODUCTION: Therapy with chimeric antigen receptor T (CART) cells for hematological malignancies has shown promising results. Effectiveness of CART cells may depend on the ratio of naive (T(N)) vs. effector (T(E)) T cells, T(N) cells being responsible for an enduring antitumor activity through mat...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Hoffmann, Jean-Marc, Schubert, Maria-Luisa, Wang, Lei, Hückelhoven, Angela, Sellner, Leopold, Stock, Sophia, Schmitt, Anita, Kleist, Christian, Gern, Ulrike, Loskog, Angelica, Wuchter, Patrick, Hofmann, Susanne, Ho, Anthony D., Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767585/
https://ncbi.nlm.nih.gov/pubmed/29375575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01956
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