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Milling solid proteins to enhance activity after melt-encapsulation

Polymeric systems for the immobilization and delivery of proteins have been extensively used for therapeutic and catalytic applications. While most devices have been created via solution based methods, hot melt extrusion (HME) has emerged as an alternative due to the high encapsulation efficiencies...

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Publicat a:Int J Pharm
Autors principals: Lee, Parker W., Maia, João, Pokorski, Jonathan K.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767079/
https://ncbi.nlm.nih.gov/pubmed/28939464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2017.09.044
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