The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein

Mucin-type O-glycosylation is the most abundant type of O-glycosylation. It is initiated by the members of the polypeptide N-acetyl-α-galactosaminyltransferase (ppGalNAc-T) family and closely associated with both physiological and pathological conditions, such as coronary artery disease or Alzheimer...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liu, Feng, Xu, Kai, Xu, Zhijue, de las Rivas, Matilde, Wang, Congrong, Li, Xing, Lu, Jishun, Zhou, Yueyang, Delso, Ignacio, Merino, Pedro, Hurtado-Guerrero, Ramon, Zhang, Yan, Wu, Fang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766936/
https://ncbi.nlm.nih.gov/pubmed/29061849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814202
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