Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate

African green monkey (AGM)-derived Vero cells have been utilized to produce various human vaccines. The Vero cell genome harbors a variety of simian endogenous type D retrovirus (SERV) sequences. In this study, a transcriptome analysis showed that DNA hypomethylation released the epigenetic repressi...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Sakuma, Chisato, Sekizuka, Tsuyoshi, Kuroda, Makoto, Kasai, Fumio, Saito, Kyoko, Ikeda, Masaki, Yamaji, Toshiyuki, Osada, Naoki, Hanada, Kentaro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766633/
https://ncbi.nlm.nih.gov/pubmed/29330501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18934-2
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