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Development of a PET radioligand for potassium channels to image CNS demyelination

Central nervous system (CNS) demyelination represents the pathological hallmark of multiple sclerosis (MS) and contributes to other neurological conditions. Quantitative and specific imaging of demyelination would thus provide critical clinical insight. Here, we investigated the possibility of targe...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Brugarolas, Pedro, Sánchez-Rodríguez, Jorge E., Tsai, Hsiu-Ming, Basuli, Falguni, Cheng, Shih-Hsun, Zhang, Xiang, Caprariello, Andrew V., Lacroix, Jerome J., Freifelder, Richard, Murali, Dhanabalan, DeJesus, Onofre, Miller, Robert H., Swenson, Rolf E., Chen, Chin-Tu, Herscovitch, Peter, Reich, Daniel S., Bezanilla, Francisco, Popko, Brian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766510/
https://ncbi.nlm.nih.gov/pubmed/29330383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18747-3
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