Development of a PET radioligand for potassium channels to image CNS demyelination

Central nervous system (CNS) demyelination represents the pathological hallmark of multiple sclerosis (MS) and contributes to other neurological conditions. Quantitative and specific imaging of demyelination would thus provide critical clinical insight. Here, we investigated the possibility of targe...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Brugarolas, Pedro, Sánchez-Rodríguez, Jorge E., Tsai, Hsiu-Ming, Basuli, Falguni, Cheng, Shih-Hsun, Zhang, Xiang, Caprariello, Andrew V., Lacroix, Jerome J., Freifelder, Richard, Murali, Dhanabalan, DeJesus, Onofre, Miller, Robert H., Swenson, Rolf E., Chen, Chin-Tu, Herscovitch, Peter, Reich, Daniel S., Bezanilla, Francisco, Popko, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766510/
https://ncbi.nlm.nih.gov/pubmed/29330383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18747-3
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