RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor three recurrent mutations (p.R44C, p.E383K and p.R416Q). Structural modeling of the most common recurrent muta...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Qutob, Nouar, Masuho, Ikuo, Alon, Michal, Emmanuel, Rafi, Cohen, Isadora, Di Pizio, Antonella, Madore, Jason, Elkahloun, Abdel, Ziv, Tamar, Levy, Ronen, Gartner, Jared J., Hill, Victoria K., Lin, Jimmy C., Hevroni, Yael, Greenberg, Polina, Brodezki, Alexandra, Rosenberg, Steven A., Kosloff, Mickey, Hayward, Nicholas K., Admon, Arie, Niv, Masha Y., Scolyer, Richard A., Martemyanov, Kirill A., Samuels, Yardena
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766496/
https://ncbi.nlm.nih.gov/pubmed/29330521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18851-4
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller