RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor three recurrent mutations (p.R44C, p.E383K and p.R416Q). Structural modeling of the most common recurrent muta...

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發表在:Sci Rep
Main Authors: Qutob, Nouar, Masuho, Ikuo, Alon, Michal, Emmanuel, Rafi, Cohen, Isadora, Di Pizio, Antonella, Madore, Jason, Elkahloun, Abdel, Ziv, Tamar, Levy, Ronen, Gartner, Jared J., Hill, Victoria K., Lin, Jimmy C., Hevroni, Yael, Greenberg, Polina, Brodezki, Alexandra, Rosenberg, Steven A., Kosloff, Mickey, Hayward, Nicholas K., Admon, Arie, Niv, Masha Y., Scolyer, Richard A., Martemyanov, Kirill A., Samuels, Yardena
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766496/
https://ncbi.nlm.nih.gov/pubmed/29330521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18851-4
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