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RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor three recurrent mutations (p.R44C, p.E383K and p.R416Q). Structural modeling of the most common recurrent muta...
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| 發表在: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5766496/ https://ncbi.nlm.nih.gov/pubmed/29330521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18851-4 |
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