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In vivo probing of nascent RNA structures reveals principles of cotranscriptional folding

Defining the in vivo folding pathway of cellular RNAs is essential to understand how they reach their final native conformation. We here introduce a novel method, named Structural Probing of Elongating Transcripts (SPET-seq), that permits single-base resolution analysis of transcription intermediate...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Incarnato, Danny, Morandi, Edoardo, Anselmi, Francesca, Simon, Lisa M., Basile, Giulia, Oliviero, Salvatore
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766169/
https://ncbi.nlm.nih.gov/pubmed/28934475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx617
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